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  Vol. 280 No. 7, August 19, 1998 TABLE OF CONTENTS
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Hormone Replacement Therapy and Heart Disease Prevention

Experimentation Trumps Observation

Diana B. Petitti, MD

JAMA. 1998;280:650-652.

Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

The true method of knowledge is experiment.—William Blake, 1788

Three different meta-analyses1-3 have concluded that estrogen replacement therapy (ERT) decreases the risk of coronary heart disease (CHD) by 35% to 50%. The predicted increase in life expectancy in hormone users, based on estimates of the risk of CHD in users of ERT derived from observational studies, is 2 to 3 years.2, 4 The effects of ERT and combined estrogen-progestin replacement therapy (HRT) on lipids and fibrinolysis are strongly beneficial for both ERT and HRT.5 This has led to extrapolation of the results of observational studies of ERT to HRT and to promotion of the use of both ERT and HRT in women with CHD.2, 6 The results of the Heart and Estrogen/progestin Replacement Study (HERS), which are reported by Hulley et al in this issue of JAMA,7 add critically important data on the effects of HRT. . . . [Full Text of this Article]

From the Department of Research and Evaluation, Kaiser Permanente Southern California, Pasadena.



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