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Proximal Myopathy Associated With Inhaled Steroids
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To the Editor: A number of undesirable systemic effects have been reported with the use of inhaled corticosteroids, including cataracts, suppression of the hypothalamic-pituitary-adrenal axis, osteoporosis, and possibly glaucoma.1-2
Report of a Case.
A 37-year-old woman who had a seizure disorder that was well controlled with carbamazepine therapy began to use a beclomethasone nasal inhaler, 42 µg of drug per nasal pump unit, 1 to 2 sprays in each nostril twice daily, for the treatment of seasonal allergic rhinitis. Four weeks later, the patient began to experience tightness in her thighs and increased fatigability when she climbed stairs or walked distances that were previously readily tolerated. Findings on a general medical examination were normal. Neurologic evaluation revealed a mild to moderate reduction in strength (4 /5 range) in neck flexion and bilaterally in shoulder abduction and hip flexion. Muscle weakness had not been noted in the past. Findings on the remainder of the neurologic . . . [Full Text of this Article]
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