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Robert F. LaPrade, MD; Marc F. Swiontkowski, MD

JAMA. 1999;281:876-878.

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

INTRODUCTION

Osteoarthritis is not simply a degenerative disorder. Rather, it is a complex derangement of articular surfaces that involves the loss of normal collagen architecture followed by an attempt by chondrocytes to produce replacement cartilage. The replacement surface is less resistant to wear than the original. Over time, full-thickness cartilage loss may develop on the articular surfaces. Symptoms of osteoarthritis include joint pain, typically worse with use and eased with rest, and joint stiffness after nonuse. The pain can become persistent.

In the past, failure of symptomatic treatment, such as nonsteroidal anti-inflammatory drugs and physical therapy, has left joint replacement as the principal option in the care of more severely affected patients. However, in recent years, 3 new intra-articular procedures have shown promise for some patients with articular cartilage defects of the knee. Multiyear follow-up has shown encouraging results for these treatments of . . . [Full Text of this Article]

Autogenous Cartilage Implantation

Autogenous Osteochondral Grafting

Hyaluronic Acid Injection

Conclusions

Author Affiliation: Department of Orthopaedic Surgery, University of Minnesota, Minneapolis.

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