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Adverse Events Associated With Ingestion of Gamma-Butyrolactone—Minnesota, New Mexico, and Texas, 1998-1999
JAMA. 1999;281:979-980.
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| Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings. |
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MMWR. 1999;48:137-140
Products containing gamma-butyrolactone (GBL)* are marketed for many claimed purposes, including to induce sleep, release growth hormone, enhance sexual activity and athletic performance, relieve depression, and prolong life. GBL is converted by the body into gamma-hydroxybutyrate (GHB), a drug banned outside of clinical trials approved by the Food and Drug Administration (FDA). Recognized manifestations of GHB toxicity include bradycardia, hypothermia, central nervous system depression, and uncontrolled movements.1 This report describes seven cases of GBL toxicity involving the product "Revivarant," which is labeled as containing 1.82 g of GBL per fluid ounce, reported from two hospital emergency departments (EDs) in Minnesota during October-December 1998 and summarizes an additional 34 cases of GBL toxicity reported to poison centers in New Mexico and Texas during October 1998-January 1999.
Minnesota
Patient 1.
On November 26, 1998, a 24-year-old man vomited and had seizures shortly after drinking 3-4 oz of Revivarant. His behavior became unusual, . . . [Full Text of this Article] Patient 2. Patient 3. Patients 4 and 5. Patients 6 and 7.
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