Intensive vs Clinical Follow-up After Treatment of Primary Breast Cancer: 10-Year Update of a Randomized Trial
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To the Editor: Two randomized trials performed in Italy1-2 failed to show any impact of intensive diagnostic follow-up on 5-year mortality for patients with primary breast cancer. We have now evaluated the mortality at 10 years in 1 of these large trials, designed to compare the effectiveness of 2 alternative follow-up protocols (intensive vs clinical) offered to study participants during the first 5 years after the treatment of primary breast cancer.
Methods.
A detailed description of the study protocol was published previously in THE JOURNAL.1 Briefly, 1243 consecutive patients surgically treated for unilateral invasive breast carcinoma with no evidence of metastases were included in the study and randomized in a 2-year period (1985-1986) by 12 participating centers in Italy. Overall, 622 patients were assigned to the intensive follow-up group and invited to have a periodic physical examination (every 3 months in the first 2 years and every 6 months thereafter) and . . . [Full Text of this Article]
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