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To the Editor: Hepatitis C virus (HCV) is the most frequent etiologic factor for non-A and non-B chronic hepatitis worldwide; moreover, a constellation of extrahepatic manifestations has been described in individuals infected with HCV.¹ Because of its lymphotropism,² HCV can represent a chronic stimulus for the immune system leading to a variety of autoimmune and lymphoproliferative disorders such as mixed cryoglobulinemia, membranoproliferative glomerulonephritis, B-cell lymphomas, and autoimmune thyroiditis.^{1, 3-5} Thyroiditis is frequently found in patients with type C chronic hepatitis during interferon therapy.⁵ Moreover, thyroiditis can be regarded as preneoplastic condition.⁶ We report the prevalence of thyroid cancer in a series of patients with chronic hepatitis C infection.

Methods.

A total of 139 patients (76 women and 63 men; mean (SD) age, 52 (14) years with positive serum anti-HCV and HCV RNA titers were consecutively investigated for thyroid involvement. The results were compared with a control group of 835 individuals (501 women . . . [Full Text of this Article]

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