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To the Editor: Glioblastoma multiforme (GBM) is a highly malignant brain tumor and has a median survival time of 1 year. Newcastle disease virus (NDV) vaccine has been reported to be effective in some patients with advanced cancers who had exhausted conventional cancer treatment.¹ We describe a patient with recurrent GBM who was treated with NDV vaccine and demonstrated objective tumor shrinkage and neurologic improvement.

Report of a Case.

A 14-year-old boy presented in September 1994 with a large left frontotemporal mass seen on a computed tomographic scan. The tumor was grossly debulked followed by 56 Gy of radiation to the tumor bed. Pathologic analysis revealed GBM (grade IV glioma). In March 1995, the patient began taking adjuvant tamoxifen citrate at 100 mg/d. By November 1995, magnetic resonance imaging (MRI) scan showed local recurrence of the tumor, and the patient was given 3600 mg/m² of cyclophosphamide with 1.5 mg of vincristine sulfate but after . . . [Full Text of this Article]