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To the Editor: The article by Drs Testa and Simonson¹ on health outcomes during improved glycemic control had some interesting, unexplained findings that raise the question of a negative impact of the trial on the placebo group. The percentage of employed patients who missed 0.5 or more days of work increased from 2.4% at baseline to 10.5% at the end of week 15 in the placebo group, compared with a decrease of 5.6% to 4.8% in the treated group. Per 500 days worked, the total days absent increased from 4.2 to 24 in the placebo group and decreased from 9.4 to 5.0 in the treated group. Bed-days (rates per 1000 person-days) had the same pattern: 921 at baseline to 1843 at the end of week 15 in the placebo group and 1653 to 1539 in the treated group. Most of the benefit attributed to improved glycemic control occurred because of . . . [Full Text of this Article]