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Stress-Induced Immunomodulation
Implications for Infectious Diseases?
Ronald Glaser, PhD;
Bruce Rabin, MD, PhD;
Margaret Chesney, PhD;
Sheldon Cohen, PhD;
Benjamin Natelson, MD
JAMA. 1999;281:2268-2270.
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INTRODUCTION
There is now significant literature showing that psychological stress can down-regulate various aspects of the cellular immune response. It is also established that communication between the central nervous system and the immune system occurs through bidirectional signals linking the nervous, endocrine, and immune systems. Psychological stressors affect the immune system by disrupting these networks. In this overview, we discuss the implications of psychological stress-associated immune modulation and risk for infectious disease.
Stress and Immune Function
At a molecular level, human immune function is mediated by the release of cytokines, nonantibody messenger molecules, from a variety of cells of the immune system, and from other cells, such as endothelial cells. We will not be discussing cytokine production by nonimmune cells since they are not known to be related to the etiology or pathogenesis of immune-mediated disease.
These cytokines subsequently . . . [Full Text of this Article]
Stress and Infection-Related Antigens
Stress and Human Immunodeficiency Virus
New Directions for Study
Author Affiliations: Department of Medical Microbiology and Immunology, Ohio State University Medical Center, Columbus (Dr Glaser); Pathology Department, University of Pittsburgh Medical Center, Clinical Immunopathology-CLSI, Pittsburgh, Pa (Dr Rabin); Department of Medicine, University of California, San Francisco (Dr Chesney); Department of Psychology, Carnegie-Mellon University, Pittsburgh (Dr Cohen); and Department of Neurosciences, New Jersey Medical School, University of Medicine and Dentistry of New Jersey, East Orange (Dr Natelson).
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