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Charles Marwick

JAMA. 1999;281:599.

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

BETHESDA, MD—A test that can identify a significant percentage of those who are likely to develop type 1 diabetes, also known as insulin-dependent or juvenile diabetes, years before the disease becomes clinically apparent has been developed and is being used in research laboratories.

The test will make it feasible to mount therapeutic intervention trials and study diet and other factors that may be involved in the development of type 1 diabetes. It might also be useful for distinguishing between type 1 and type 2 (non–insulin-dependent) diabetes, say the investigators concerned.

In type 1 diabetes, which is an autoimmune disease involving destruction of the insulin-producing beta cells in the pancreas, the autoimmune response is directed against several beta cell antigens. Two of these antigens appear to be particularly important: glutamic acid decarboxylase (GAD) and IA-2, a recently isolated member of the protein tyrosine phosphatase family.

Abner L. Notkins, . . . [Full Text of this Article]

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