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To the Editor: Dr Holmes and colleagues¹ reported that analysis of data from the Nurses' Health Study found no evidence that a lower intake of dietary fat was associated with a decreased risk of breast cancer. These results, in a well-defined, prospective cohort study, differ from those of retrospective studies, international comparisons, meta-analyses of case-control studies, and laboratory animal studies.

Martinez et al,² in a study of the relation of dietary calcium and vitamin D to the risk of colorectal cancer in the same group of women, found that vitamin D intake in these women was considerably higher than the US average, primarily due to their regular intake of multivitamin supplements. The average US woman consumed about 60 IU (1.5 µg) of vitamin D in 1987,³ while the women in the Nurses' Health Study had a median daily intake of more than 250 IU (6.25 µg), about 4-fold higher.

Garland . . . [Full Text of this Article]

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Association of Dietary Intake of Fat and Fatty Acids With Risk of Breast Cancer
Michelle D. Holmes, David J. Hunter, Graham A. Colditz, Meir J. Stampfer, Susan E. Hankinson, Frank E. Speizer, Bernard Rosner, and Walter C. Willett
JAMA. 1999;281(10):914-920.
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