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To the Editor: Drs Antman and Shea¹ add to the confusion concerning screening women aged 40 to 49 years for breast cancer. The Canadian trial² the authors cite did not have sufficient statistical power to evaluate women in this age group in the early years of follow-up. Furthermore, the 19 Canadian women cited in the article already had advanced breast cancer at the time they were randomized to have mammography, while only 5 with breast cancer were assigned to the control group.

The authors fail to point out that the screening trials were never intended to permit the analysis of women between 40 and 49 years as a separate subgroup and lacked statistical power to do so. The cutpoint between 49 and 50 years is a contrivance that resulted from data grouping. Many of the parameters of screening (recall rates and recommendations for biopsy rates) are the same, regardless of . . . [Full Text of this Article]

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RELATED ARTICLE

Screening Mammography Under Age 50
Karen Antman and Steven Shea
JAMA. 1999;281(16):1470-1472.
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