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Leptin Link to Hypertension
Rebecca Voelker
JAMA. 1999;282:1322.
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Researchers in Japan say they have demonstrated for the first time a direct link between blood levels of the hormone leptin and hypertension.
The researchers, from Sapporo Medical University, had shown earlier that blood levels of leptin, which is believed to help regulate body weight, were higher in hypertensive people of normal weight than in nonhypertensive individuals of normal weight. Their latest study analyzed blood leptin levels, blood pressure, and insulin sensitivity in 133 men and 263 women under age 65 who did not have diabetes or a history of drug treatment for hypertension.
After controlling for age, body mass index, and insulin resistance, the researchers found that men with high leptin levels were more likely than those with lower levels to have elevated diastolic blood pressure. "It is possible that leptin is one of the regulators of blood pressure," said Hideki Takizawa, MD, lead author of the . . . [Full Text of this Article]
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