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  Vol. 282 No. 16, October 27, 1999 TABLE OF CONTENTS
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  From the Centers for Disease Control and Prevention: Morbidity and Mortality Weekly Report
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Inadvertent Use of Bicillin® C-R for Treatment of Syphilis—Maryland, 1998

JAMA. 1999;282:1513-1514.

Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

MMWR. 1999;48:777-779

In October 1998, the Maryland Department of Health and Mental Hygiene (MDH) was notified that a public sexually transmitted disease (STD) clinic in a county (county A) had used a nonrecommended preparation to treat syphilis patients during January-October 1998. The clinic had been inadequately treating syphilis patients or syphilis contacts with Bicillin®* C-R (a mixture of 1.2 million units [MU] benzathine penicillin G [BPG] and 1.2 MU procaine penicillin G), rather than with Bicillin® L-A (2.4 MU BPG). Compared with short-acting procaine penicillin G, BPG has a longer half-life considered essential for effective syphilis treatment because it yields sustained spirochetecidal levels needed to treat the slowly reproducing agent of syphilis, Treponema pallidum. The inadvertent use of Bicillin C-R, which contains only half the recommended dose of BPG for syphilis, was recognized by a health-care provider at the STD clinic in a neighboring county (county B) approximately 1 month . . . [Full Text of this Article]



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