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High-Dose Chemotherapy for Breast Cancer
Karen H. Antman, MD;
Daniel F. Heitjan, PhD;
Gabriel N. Hortobagyi, MD
JAMA. 1999;282:1701-1703.
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INTRODUCTION
Breast cancer incidence and mortality have been stable or declining since about 1992, the first decline since statistics were available.1-2
While screening has resulted in a higher percentage of patients with early stage disease and improved survival, mortality at 10 years exceed 60% for those with 10 or more involved lymph nodes or large primary tumors. Virtually all patients who initially present with or later develop metastatic breast cancer ultimately die of their disease.3-4
Of 1581 women with metastatic breast cancer treated at M. D. Anderson Cancer Center with the conventional dose of 5-fluorouracil doxorubicin and cyclophosphamide, only 263 (17%) obtained a complete response and 49 (3%) were in the same complete response 5 years later. Currently, 26 (1.3%) are in complete response.5 Event-free survivors were only found among women who achieved a complete response to chemotherapy, which . . . [Full Text of this Article]
Adjuvant Trials
Metastatic Disease Studies
Author Affiliations: Herbert Irving Comprehensive Cancer Center, Columbia University, New York, NY (Drs Antman and Heitjan) and the M. D. Anderson Cancer Center, University of Texas, Austin (Dr Hortobagyi).
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