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Helle Krogh Johansen, MD, DMSc; Peter C. Gøtzsche, MD, DMSc

JAMA. 1999;282:1756-1757.

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

APPENDIX

We identified 12 relevant reports,^1-12 of which 3 were subsequently excluded. A trial in which only 12 patients received nystatin had failed due to serious problems with compliance⁹; another reported only the number of "Candida-free" days (which was 18 for both nystatin and placebo)¹⁰; the third report was a duplicate publication.¹¹ Of the 9 included trials, 1 was published as an abstract only.⁸

The drugs were given prophylactically in 7 trials and as treatment in 2.^{6, 12} Acute leukemia was the most common disease in 6 trials; 1 trial concerned patients receiving a liver transplant⁷; 1, critically ill surgical and trauma patients³; and 1, patients with acquired immunodeficiency syndrome.¹² Nystatin was compared with placebo in 3 trials^1-3 and with fluconazole in 6^4-8,12; all drugs were given orally. In total, 537 patients received nystatin, 147 . . . [Full Text of this Article]

Author Affiliations: The Nordic Cochrane Centre, Rigshospitalet, Copenhagen, Denmark.

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