This Article  • Full text  • PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Citing articles on Web of Science (18)  • Contact me when this article is cited  Related Content  • Similar articles in JAMA  Social Bookmarking   What's this?

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

To the Editor: Bupropion hydrochloride, an atypical antidepressant that has both dopaminergic and adrenergic actions, is effective for smoking cessation, being more effective than placebo¹ and more effective than the nicotine patch alone.² Bupropion enhances the response rate of the nicotine patch. Recent guidelines on smoking cessation³ recommend bupropion for smokers who fail treatment with or who do not wish to use nicotine replacement therapy. It is the second-line therapy in part due to adverse effects.⁴ Principally, these include agitation, dizziness, insomnia, tremor, reduced seizure threshold, dry mouth, nausea, and abdominal pain. A study by Settle⁴ found that these adverse effects are dose related. Compared with placebo, which had a 4% discontinuation rate, buproprion had a discontinuation rate of 9% at the 300 mg/d dosage and 11% at 450 mg/d dosage. We describe herein a serum sickness–like reaction in a man taking bupropion.

Report of a Case

A 21-year-old white man began taking bupropion . . . [Full Text of this Article]

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Cutaneous Reactions to Drugs in Children
Segal et al.
Pediatrics 2007;120:e1082-e1096.
ABSTRACT | FULL TEXT  

Bupropion Sustained Release for Treatment of Tobacco Dependence
Hays and Ebbert
Mayo Clin Proc. 2003;78:1020-1024.
ABSTRACT