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Martin J. Blaser, MD

JAMA. 1999;282:2260-2262.

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

Helicobacter pylori is a bacterium that is a long-term inhabitant of the human stomach, usually persisting for the lifetime of its host. Individuals who carry H pylori are at higher risk for developing peptic ulcer disease and noncardiac gastric carcinoma than those who do not carry the organism.¹ Although carriage is neither necessary nor sufficient to explain either disease, physicians have become increasingly concerned with H pylori since the recognition that eliminating its colonization often changes the natural history of peptic ulcer disease.² In many parts of the world, especially in developing countries, the preponderance of adults carry H pylori.³ Helicobacter pylori is acquired early in life; by age 10 years, more than 50% of children worldwide carry this organism.³ Thus, it is important to understand where H pylori, so common in human ecology, originates.

In animals, the stomach has an indigenous microbiota (flora), . . . [Full Text of this Article]

Author Affiliation: Division of Infectious Diseases, Department of Medicine, Vanderbilt University School of Medicine, and the Department of Veterans Affairs Medical Center, Nashville, Tenn.

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