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Safety of Antidepressant Use in Pregnant and Nursing Women
Lynne Lamberg
JAMA. 1999;282:222-223.
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Washington—New research may help physicians who treat depressed pregnant or nursing women better assess the benefits and risks of drug and nondrug therapies for both mother and child.
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The ideal: contented mother and happy infant. (Photo credit: Photodisc)
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Selective serotonin reuptake inhibitors (SSRIs) commonly used as antidepressants generally demonstrate incomplete placental passage, with low or undetectable amounts in the umbilical cord at delivery, said Zachary Stowe, MD, of Emory University School of Medicine, Atlanta. Stowe spoke at one of several sessions on depression in pregnant and nursing women at the annual meeting of the American Psychiatric Association (APA) here in May.
His laboratory studies in pregnant rats, however, indicate that antidepressant concentrations in the developing brain achieve higher-than-expected concentrations, he said, up to 85% of that in the maternal brain, since antidepressants are sequestered in the more lipophilic brain tissue. These findings, he said, suggest that the . . . [Full Text of this Article]
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