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Diuretics for Hypertension
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| Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings. |
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To the Editor: We take exception to Dr Moser's1 labeling of our study2 as widely disseminated misinformation. We showed that in patients who were treated with calcium antagonists, the decrease in ventricular arrhythmias paralleled a decrease in left ventricular (LV) mass. In contrast, patients who were treated with a diuretic experienced no reduction of LV mass or associated ventricular arrhythmias despite a similar decrease in arterial pressure. The article was peer reviewed, revised, and published. Clearly, 10 years later, a variety of potential criticisms could be raised, not the least of which is that the study duration probably was too short. However, this does not make the article "misinformation."
We also do not share Moser's enthusiasm about diuretics being as effective as or more effective than other antihypertensive drugs in reducing LV mass, in part because of 2 selected studies. In the Treatment of Mild Hypertension Study,3 very few patients . . . [Full Text of this Article]
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