 |
|
Pemphigus—Diseases of Antidesmosomal Autoimmunity
Mark C. Udey, MD, PhD;
John R. Stanley, MD
JAMA. 1999;282:572-576.
|
|
| Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings. |
|
|
|
CASE PRESENTATION
A 78-year-old white man was referred to the Dermatology Branch of the National Cancer Institute (NCI), Bethesda, Md, with a 5-month history of a bullous disorder. The patient initially went to a community dermatologist and presented with gingival and buccal erosions and with occasional flaccid blisters, crusted papules, and plaques involving the scalp, back, and chest. A provisional diagnosis of pemphigus vulgaris (PV) was made, and although biopsy results were nondiagnostic, indirect immunofluorescence testing revealed deposits of IgG on the surfaces of keratinocytes in monkey esophagus. He initially received prednisone (60 mg/d) and tetracycline hydrochloride (500 mg 4 times per day), but the regimen was changed to prednisone (100 mg/d) and azathioprine (100 mg/d) 2 weeks later because of an inadequate clinical response. The patient's disease remained active over the next 4 months despite treatment with prednisone ( 60 mg/d) and . . . [Full Text of this Article]
DISCUSSION
Clinical and Histologic Features of Pemphigus Pathophysiology of Pemphigus Therapy
CONCLUSIONS
Author Affiliations: Dermatology Branch, Division of Clinical Sciences, National Cancer Institute, Bethesda, Md (Dr Udey); and the Department of Dermatology, University of Pennsylvania, Philadelphia (Dr Stanley).
 CiteULike  Connotea  Del.icio.us  Digg  Reddit  Technorati  Twitter
What's this?
RELATED ARTICLE
August 11, 1999
JAMA. 1999;282(6):603-604.
EXTRACT
| FULL TEXT
THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES
|
ELISA Testing of Anti-Desmoglein 1 and 3 Antibodies in the Management of Pemphigus
Abasq et al.
Arch Dermatol 2009;145:529-535.
ABSTRACT
| FULL TEXT
Pemphigus IgG Causes Skin Splitting in the Presence of Both Desmoglein 1 and Desmoglein 3
Spindler et al.
Am. J. Pathol. 2007;171:906-916.
ABSTRACT
| FULL TEXT
Desmoglein Versus Non-desmoglein Signaling in Pemphigus Acantholysis: CHARACTERIZATION OF NOVEL SIGNALING PATHWAYS DOWNSTREAM OF PEMPHIGUS VULGARIS ANTIGENS
Chernyavsky et al.
J. Biol. Chem. 2007;282:13804-13812.
ABSTRACT
| FULL TEXT
Dissecting the Anti-Desmoglein Autoreactive B Cell Repertoire in Pemphigus Vulgaris Patients
Qian et al.
J. Immunol. 2007;178:5982-5990.
ABSTRACT
| FULL TEXT
Novel Mechanisms of Target Cell Death and Survival and of Therapeutic Action of IVIg in Pemphigus
Arredondo et al.
Am. J. Pathol. 2005;167:1531-1544.
ABSTRACT
| FULL TEXT
Mechanisms of Blister Formation by Staphylococcal Toxins
Hanakawa and Stanley
J Biochem 2004;136:747-750.
ABSTRACT
| FULL TEXT
Desmosomes: interconnected calcium-dependent structures of remarkable stability with significant integral membrane protein turnover
Windoffer et al.
J. Cell Sci. 2002;115:1717-1732.
ABSTRACT
| FULL TEXT
Classification, Clinical Manifestations, and Immunopathological Mechanisms of the Epithelial Variant of Paraneoplastic Autoimmune Multiorgan Syndrome: A Reappraisal of Paraneoplastic Pemphigus
Nguyen et al.
Arch Dermatol 2001;137:193-206.
ABSTRACT
| FULL TEXT
Novel Human {alpha}9 Acetylcholine Receptor Regulating Keratinocyte Adhesion is Targeted by Pemphigus Vulgaris Autoimmunity
Nguyen et al.
Am. J. Pathol. 2000;157:1377-1391.
ABSTRACT
| FULL TEXT
Pemphigus Vulgaris Antibody Identifies Pemphaxin. A NOVEL KERATINOCYTE ANNEXIN-LIKE MOLECULE BINDING ACETYLCHOLINE
Nguyen et al.
J. Biol. Chem. 2000;275:29466-29476.
ABSTRACT
| FULL TEXT
|
