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M. J. Friedrich

JAMA. 1999;282:621-622.

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

Chicago—As therapeutic strategies for Alzheimer disease (AD) begin to emerge, interest has focused on identifying signs of mental decline as early as possible to prevent, delay, or reverse disease-associated brain damage. Experts in the field say a condition known as mild cognitive impairment (MCI), which precedes development of AD and other dementias in many people, appears to be a signal of disease onset that will help target individuals for early interventions.

Forgetting the past; fearing the future. (Photo credit: Leah Melnick)

A measurable memory loss that is abnormal for an individual's age and education characterizes MCI, said Ronald Petersen, PhD, MD, director of the Mayo Alzheimer's Disease Center. The memory deficits of MCI are not accompanied by decline in other cognitive abilities, such as attention and language, as occurs in dementia, he said. But many people with MCI develop AD, and it seems, said Petersen, that . . . [Full Text of this Article]

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