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Perinatal HIV Prevention
Joan Stephenson, PhD
JAMA. 1999;282:625.
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| Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings. |
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A single oral dose of the antiretroviral drug nevirapine given to both an HIV-infected woman and her newborn infant provides the most practical and cheapest way to prevent transmission of the infection from mother to child, according to a study sponsored by the National Institute of Allergy and Infectious Diseases (NIAID).
Researchers at Makerere University in Kampala, Uganda, and Johns Hopkins University in Baltimore gave one group of HIV-infected women a single dose of nevirapine during labor and another dose to their infants within 3 days of birth. A second group of HIV-infected women received a short course of zidovudine (AZT) every 3 hours from the onset of labor until delivery, and their infants were given the drug twice a day during the first week after birth.
The trial was halted when an analysis of interim data found that only 13.1% of infants from the nevirapine group . . . [Full Text of this Article]
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