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The Dilemma Facing HIV-Infected Women in Resource-Poor Settings

Mary Glenn Fowler, MD, MPH; Jeanne Bertolli, PhD; Philip Nieburg, MD, MPH

JAMA. 1999;282:781-783.

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

The successful implementation of the Pediatric AIDS Clinical Trials Group Protocol 076 (PACTG 076) zidovudine regimen for prevention of perinatal human immunodeficiency virus (HIV) transmission, in which HIV-infected women receive oral zidovudine during pregnancy, intravenous zidovudine during labor, and neonates receive 6 weeks of oral zidovudine, has led to dramatic reductions in pediatric acquired immunodeficiency syndrome (AIDS) in the United States and Europe.^1-2 In stark contrast, health care workers in resource-poor settings such as sub-Saharan Africa struggle with 1600 new perinatal HIV infections daily³ and watch the increases in HIV-related infant mortality reverse the hard-won gains in child survival related to immunization, oral rehydration, and breastfeeding programs.

Transmission of HIV during pregnancy, labor, and delivery is only part of the issue in many areas of the world. Even prior to zidovudine interventions, striking disparities in perinatal HIV-infection rates . . . [Full Text of this Article]

Author Affiliations: Maternal Child Transmission and Adolescent Studies Section, Epidemiology Branch, Division of HIV/AIDS Prevention—Surveillance/Epidemiology (Drs Fowler and Bertolli); National Center for HIV, STD, and TB Prevention, Office of the Director (Dr Nieburg), Centers for Disease Control and Prevention, Atlanta, Ga.

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