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To the Editor: Several articles on the clinical utility of cranberry juice in patients with recurrent urinary tract infections have been published.^1-3 Older studies attributed antibacterial activity to organic acids such as hippuric acid.⁴ However, more recent studies have emphasized the role of components that act by interference with bacterial adherence of Escherichia coli.⁵ Thus, it seemed important to reassess whether cranberry juice has true broad-spectrum direct antibacterial activity.

Methods

We tested a 5-fold concentrated preparation of the juice to simulate the cranberry concentrate currently available commercially. The concentrate was diluted 1:1 with trypticase soy broth and adjusted to a pH of 7.0 to ensure that the results would not be confounded by the acidity of the medium. We added an inoculum of approximately 104 colony-forming units per milliliter from an overnight culture of a variety of American Type Culture Collection–quality control strains both to plain broth and the broth . . . [Full Text of this Article]

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THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Anti-microbial Activity of Urine after Ingestion of Cranberry: A Pilot Study
Lee et al.
Evid Based Complement Alternat Med 2008;0:nem183v1-nem183.
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