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Merits, Flaws of Live Virus Flu Vaccine Debated
Charles Marwick
JAMA. 2000;283:1814-1815.
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WashingtonDespite recent studies reporting its efficacy in preventing flu, particularly in children, the latest live virus candidate vaccine against influenza (FluMist, Aviron, Mountain View, Calif), faces an uphill road on its way to licensure. Some evidence for this conclusion appears in a newly published report of a workshop held in December 1998 at the Paul Ehrlich Institute in Langen, Germany (Biologicals. In press).
The workshop was attended by representatives of US and European public health agencies, regulatory authorities, academic scientists, and manufacturers, said Reinhard Kurth, MD, president of the Paul Ehrlich Institute, in an interview.
Several live virus influenza vaccines have been developed in the past 25 years or so; the agent of current interest was devised in the late 1980s by Hunein F. Maassab, PhD, a professor in the University of Michigan School of Public Health. In this vaccine, three of the six nonstructural viral . . . [Full Text of this Article]
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