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To the Editor: We previously reported a randomized controlled trial to assess the induction of immunologic memory in children (15-23 months) previously given 2 doses of either meningococcal C conjugate vaccine or plain quadrivalent meningococcal polysaccharide vaccine, separated by 2 months.¹ The conjugate vaccination primed for a memory IgG antimeningococcal C antibody response to a dose of plain quadrivalent meningococcal vaccine given 1 year later.¹ In contrast, the group initially given the plain meningococcal vaccine showed evidence of hyporesponsiveness. While the clinical significance is unknown, theoretically, these children might be at increased risk for invasive serogroup C meningococcal disease if exposed. Therefore, we carried out an open-label extension of the previous study at the 3 original sites to determine if a dose of meningococcal C conjugate vaccine could overcome this hyporesponsive state.

Methods

Children who had received either 2 doses of plain meningococcal vaccine 2 months apart followed by a third . . . [Full Text of this Article]

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