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To the Editor: Dr Visser and colleagues¹ reported elevated levels of C-reactive protein (CRP) in otherwise healthy overweight and obese individuals, suggesting a state of chronic low-grade systemic inflammation. The authors, in their rationale for measuring CRP, cited studies showing an association between adipose tissue and the proinflammatory cytokine interleukin 6 (IL-6), but they did not measure serum concentrations of IL-6.

We have demonstrated a positive association between obesity and plasma IL-6 levels in humans.² In this study, we also showed that IL-6 levels were significantly increased in middle-aged obese individuals with sleep apnea and suggested that IL-6 might play a role in mediating sleepiness and fatigue in these subjects. In a new controlled study that included 3 groups (normal weight control subjects, obese subjects without sleep apnea, and obese subjects with sleep apnea, the latter 2 groups matched for body mass index), we found that plasma concentrations of both . . . [Full Text of this Article]

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