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To the Editor: Nitric oxide–mediated damage has been implicated in a number of neurological diseases including stroke^1-2 and multiple sclerosis (MS).³ For instance, monocytes expressing high levels of nitric oxide synthetase have been found in plaques from the brains of patients with MS.⁴ The proximal agent of neuronal cell damage may be peroxynitrite, which is formed in vivo from the synthesis of nitric oxide and superoxide.

Uric acid is a known peroxynitrite scavenger, and several lines of evidence suggest that high serum levels of uric acid may offer protection against development of MS. For instance, a survey of 20 million patient records revealed that MS and gout were mutually exclusive diagnoses.⁴ In a murine model of MS, administration of uric acid was found to have a linear dose-response protective effect, and patients with MS have lower levels of uric acid than controls.^4-5 To further assess this possible inverse relationship between . . . [Full Text of this Article]

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