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Jerry A. Shields, MD; Carol L. Shields, MD; Jose Luis Tovilla-Canales, MD; Gary V. Mercado, MD; Hormoz Ehya, MD

JAMA. 2000;283:178.

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

Malignant neoplasms occasionally metastasize to intraocular structures. Most intraocular metastases occur in the uveal tract (iris, ciliary body, and choroid).¹ Metastasis most often develops in the choroid (88%) and less often in the iris (9%) and ciliary body (3%).² Metastasis from breast and lung cancers accounts for most intraocular metastasis.² In 25% of patients who present with uveal metastasis, the intraocular lesion represents the first manifestation of systemic cancer.²

A 60-year-old woman sought ophthalmic evaluation for a recently recognized mass on her left iris. She denied prior cancer and history of breast lesions. Her visual acuity was 20/60 in the affected left eye. Examination disclosed a fleshy iris mass (Figure 1) that measured 13 mm in base and 5 mm in thickness. Fluorescein angiography showed it to be highly . . . [Full Text of this Article]

Author Affiliations: Oncology Service (Drs J. Shields, Tovilla-Canales, C. Shields, and Mercado), Wills Eye Hospital, Thomas Jefferson University, Philadelphia, Pa; and the Department of Pathology, Fox Chase Cancer Center, Philadelphia (Dr Ehya).