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Bradley A. Perkins, MD

JAMA. 2000;283:2842-2844.

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

With near elimination of Haemophilus influenzae type b (Hib) disease through use of conjugate vaccines in many countries and newly available pneumococcal conjugates, prevention of meningococcal disease is an increasingly important priority for control of bacterial meningitis. The elegant meningococcal vaccine immunogenicity study by MacLennan and colleagues¹ in this issue of THE JOURNAL is another example of how polysaccharide protein conjugation can overcome the immunologic shortcomings of plain polysaccharide vaccines in infants and young children.

Two critical points for evaluation of meningococcal conjugate vaccines are well demonstrated: first, the usefulness of including a measure of functional antibody activity, such as the serum bactericidal activity (SBA), and the enzyme-linked immunosorbent assay (ELISA) measurements; and second, the use of plain polysaccharide vaccine, in addition to the conjugate vaccine, to test the hypothesis that immunologic memory was induced. The consideration of both of these issues in the design of . . . [Full Text of this Article]

Author Affiliation: Division of Bacterial and Mycotic Diseases, Centers for Disease Control and Prevention, Atlanta, Ga.

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Safety, Immunogenicity, and Induction of Immunologic Memory by a Serogroup C Meningococcal Conjugate Vaccine in Infants: A Randomized Controlled Trial
Jenny M. MacLennan, Fiona Shackley, Paul T. Heath, Jonathan J. Deeks, Caroline Flamank, Mark Herbert, Helen Griffiths, Eva Hatzmann, Christian Goilav, and E. Richard Moxon
JAMA. 2000;283(21):2795-2801.
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