This Article  • Full text  • PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citing articles on HighWire  • Citing articles on Web of Science (1)  • Contact me when this article is cited  Related Content  • Related article  • Similar articles in JAMA  Social Bookmarking   What's this?

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

To the Editor: The Consensus Statement on antiretroviral therapy in adults by Dr Carpenter and colleagues¹ contains an inaccuracy regarding the effect of coadministration of ritonavir on the exposure of saquinavir in the soft-gelatin formulation (saquinavir SGF). Table 2 states that ritonavir coadministration results in an increase in saquinavir exposure (area under the plasma concentration curve [AUC]) of 121%. This estimate, however, is too low by greater than an order of magnitude.²

The increase of 121% results from a comparison of the 24-hour saquinavir exposures obtained with the combination of 400 mg of ritonavir twice daily plus 400 mg of saquinavir SGF twice daily against exposures obtained with saquinavir SGF, 1200 mg, administered 3 times daily (the licensed dosage).^3-4 This comparison was previously presented because it was considered to be clinically meaningful in view of the wide use of the ritonavir, 400 mg, and saquinavir SGF, 400 mg, twice daily . . . [Full Text of this Article]

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?

RELATED ARTICLE

Antiretroviral Therapy in Adults: Updated Recommendations of the International AIDS Society–USA Panel
Charles C. J. Carpenter, David A. Cooper, Margaret A. Fischl, Jose M. Gatell, Brian G. Gazzard, Scott M. Hammer, Martin S. Hirsch, Donna M. Jacobsen, David A. Katzenstein, Julio S. G. Montaner, Douglas D. Richman, Michael S. Saag, Mauro Schechter, Robert T. Schooley, Melanie A. Thompson, Stefano Vella, Patrick G. Yeni, and Paul A. Volberding
JAMA. 2000;283(3):381-390.
ABSTRACT | FULL TEXT  

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Model-based Analysis of the Pharmacokinetic Interactions Between Ritonavir, Nelfinavir, and Saquinavir after Simultaneous and Staggered Oral Administration
Lu et al.
Drug Metab. Dispos. 2002;30:1455-1461.
ABSTRACT | FULL TEXT