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Mark E. Cooper, MB, BS, PhD; Colin I. Johnston, MB, BS

JAMA. 2000;283:3177-3179.

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

INTRODUCTION

Recent guidelines have emphasized that the target blood pressure levels for patients with diabetes should be lower than in other hypertensive groups.^1-2 These recommendations are based on various studies interpreted to conclude that aggressive blood pressure reduction in this population is associated not only with a reduced rate of progression of renal disease but also a decreased incidence of cardiovascular events. This decrease in cardiovascular events is especially relevant to patients with diabetes, who have at least a 2-fold increase in cardiovascular mortality that is further increased by concomitant hypertension.³

Blood Pressure and Cardiovascular Disease

Epidemiological studies in patients with diabetes have found a close correlation between blood pressure level and cardiovascular mortality.⁴ Post-hoc analyses of studies performed more than 10 years ago, such as the Systolic Hypertension in the Elderly Program (SHEP) study,⁵ have found that antihypertensive therapy may reduce the rate of . . . [Full Text of this Article]

Lower Blood Pressure Target Levels

ACE Inhibitors vs Other Antihypertensive Therapies

ACE Inhibitors vs CCBs

ACE Inhibitors vs -Blockers

ACE Inhibitors and Secondary Prevention

Other Risk Factors

Conclusion

Author Affiliations: Department of Medicine, University of Melbourne, Austin and Repatriation Medical Centre, Heidelberg, Australia (Drs Cooper and Johnston) and Baker Medical Research Institute, Melbourne, Australia (Dr Johnston).

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