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To the Editor: Human papillomavirus type 16 (HPV 16) is the HPV type most frequently detected in human cancers and is associated with an increased risk of cervical and lower anogenital tract tumors. Some researchers have speculated that HPV infection may play a role in prostate cancer, a common malignancy among men, based on an association of this cancer with sexual activities.¹ However, studies of HPV 16 DNA in prostate cancer tissues have shown inconsistent results.^2-3

Methods

The association of prostate cancer risk with the presence of HPV 16 antibody was examined in a nested case-control study within the Child Health and Development Study cohort, which enrolled members of the Kaiser Foundation Health Plan residing in the Oakland, Calif, area between 1959 and 1966.⁴ Cancer cases were identified from more than 13,000 men in this cohort by linkage with the California Cancer Registry through October 1993 (estimated to have been 97% . . . [Full Text of this Article]

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