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To the Editor: The incidence of cutaneous malignant melanoma is increasing more rapidly than that of any other cancer among the white population.¹ Melanomas cause more than 75% of all skin cancer deaths.² Because the Breslow³ thickness of a primary tumor is related to its metastatic potential, this factor often guides surgical management. However, some thin melanomas can metastasize despite a favorable Breslow thickness.⁴ Therefore, better prognostic factors are required for definition of malignant potential.

Pololike kinase (PLK), which codes for a serine/threonine kinase, regulates multiple steps of mitotic progression and is highly conserved from yeast to humans. Our previous studies revealed that levels of PLK transcripts and PLK protein in human tumors correlate with the rate of cell division, suggesting that PLK may be a marker of cellular proliferation.^5-6

Methods

To examine the prognostic significance of PLK expression in melanomas, we investigated 175 patients (94 female, 81 male) with superficial . . . [Full Text of this Article]

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