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JAMA. 2000;283:733.

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

On December 22/29, 1999, JAMA Medical News & Perspectives included thoughts for the future from NIH directors. Here are the views of two additional institutes.

NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

Twenty years from now, we'll understand the genetic basis of single-gene inherited diseases. In addition, we will know the genetic basis for the more common, complex genetic disorders diabetes mellitus types 1 and 2 and obesity. We'll be able to stem the tide of overweight and obesity in the United States by applying new approaches to prevention and treatment of these disorders. While our efforts to bolster translational, clinical, and behavioral research will be successful, the ethical, legal, and social implications of genetic discoveries will continue to pose challenges.

Through trans–National Institutes of Health efforts of this institute and others, advances in immunology will uncover the basis for and means to prevent and treat most autoimmune . . . [Full Text of this Article]