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Joan Stephenson, PhD

JAMA. 2000;283:870.

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

New Orleans—Stem cell transplants appear to be substantially more effective than bone marrow transplantation for certain high-risk leukemia and lymphoma patients, according to a new study by researchers at the Fred Hutchinson Cancer Research Center in Seattle. The prospective randomized trial, presented here at the annual meeting of the American Society of Hematology, is the largest to date to compare outcomes of patients who undergo transplantation with bone marrow or stem cells.

Although bone marrow transplantation is a standard treatment for many hematologic malignancies, the preliminary findings from the new study indicate that peripheral blood stem cell transplantation offers improved overall and disease-free survival in patients with advanced-stage disease. The study also suggests that complication rates for the two procedures were comparable, at least in the short term.

CONVINCING EVIDENCE

"The evidence is convincing enough that we've already made a change in treating our high-risk patients," . . . [Full Text of this Article]

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