This Article  • Full text  • PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Citing articles on Web of Science (12)  • Contact me when this article is cited  Related Content  • Related article  • Similar articles in JAMA  Social Bookmarking   What's this?

Plausible Theory, Negative Clinical Trial

Bennett A. Shaywitz, MD; Sally E. Shaywitz, MD

JAMA. 2000;283:1055-1056.

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

Whether to use estrogen replacement therapy in postmenopausal women continues to represent a major concern for women and their physicians. In the last few years, it has become clear that estrogen exerts a wide range of effects, including (in addition to its effects on reproduction) effects on the cardiovascular system,¹ skeletal system² and, of particular interest, neuronal systems serving cognitive function, especially memory.^3-7

There are good biological reasons to suspect that estrogen may influence cognition in postmenopausal women. Preclinical evidence suggests that estrogen exerts neuronal effects through mechanisms involving both genomic and cell surface receptors. Two estrogen receptors, and , are expressed in brain tissue and appear to be involved in the genomic effects.⁸ Nongenomic cell surface actions are known as well, with mechanisms that involve second messenger systems and effects on neuronal excitability and ion channels. Effects of estrogen may be . . . [Full Text of this Article]

Author Affiliations: National Institute of Child Health and Human Development–Yale Center for the Study of Learning and Attention, Department of Pediatrics, Yale University School of Medicine, New Haven, Conn.

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?

RELATED ARTICLE

Estrogen Replacement Therapy for Treatment of Mild to Moderate Alzheimer Disease: A Randomized Controlled Trial
Ruth A. Mulnard, Carl W. Cotman, Claudia Kawas, Christopher H. van Dyck, Mary Sano, Rachelle Doody, Elizabeth Koss, Eric Pfeiffer, Shelia Jin, Anthony Gamst, Michael Grundman, Ronald Thomas, Leon J. Thal, and for the Alzheimer's Disease Cooperative Study
JAMA. 2000;283(8):1007-1015.
ABSTRACT | FULL TEXT  

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Trolox and 17{beta}-Estradiol Protect against Amyloid {beta}-Peptide Neurotoxicity by a Mechanism That Involves Modulation of the Wnt Signaling Pathway
Quintanilla et al.
J. Biol. Chem. 2005;280:11615-11625.
ABSTRACT | FULL TEXT  

Aggregate Changes in Severe Cognitive Impairment Among Older Americans: 1993 and 1998
Freedman et al.
Journals of Gerontology Series B: Psychological Sciences and Social Science 2001;56:100S-111.
ABSTRACT | FULL TEXT