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To the Editor: In our review of cases of thymoma,¹ we discovered several patients with multiple neoplasms. These patients were not necessarily treated with radiation therapy or found to have a history of myasthenia gravis, suggesting that the association between thymoma and cancer may be intrinsic and not due to treatment or thymoma-associated conditions.

Methods

A total of 136 patients with a histologic diagnosis of thymoma were evaluated.¹ Additional malignancies were recorded through chart review, corresponding physician notes, and the hospital tumor registry.

Results
Additional neoplasms were noted in 38 patients (28%). Fourteen patients had at least 3 unrelated neoplasms. No histologic subtype of thymoma was more strongly associated with additional neoplasms. Six patients with additional neoplasms never underwent thymic resection.

Forty-six patients received radiation or chemotherapy for their thymoma. Among these, 16 (35%) developed second neoplasms. This rate did not differ significantly from the incidence in those who did not . . . [Full Text of this Article]

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