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Harold C. Slavkin, DDS; Bruce J. Baum, DMD, PhD

JAMA. 2000;284:1215-1217.

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

INTRODUCTION

The classic dental diseases, caries and periodontal disease, are commonly thought to have little effect on systemic health. These diseases result from infections by microbes with highly specific adhesion mechanisms in the mouth.¹ Systemic disease resulting from infectious oral microbes is generally recognized to occur in patients with immunological and nutritional deficiencies, such as when individual host defenses are compromised, allowing oral microbes to gain systemic access. Systemic complications from oral microbes are usually thought to be confined to only a few specific clinical scenarios, such as bacterial endocarditis.² Given this perspective, it is understandable that primary care physicians pay little attention to oral microbial infections and dental diseases.³

However, in view of the results of recent studies that examined the relationship of oral and dental infections to chronic cardiovascular disease and other systemic illnesses, such inattention can no longer be . . . [Full Text of this Article]

Prevalence of Dental Diseases

Dental Infection as a Risk Factor for Atherosclerotic Disease

Additional Possible Risks From Dental Infections

Links Between Oral Disease and General Health

Attention to Dental and Oral Diseases and Resulting Medical Outcomes

Author Affiliations: Office of the Director (Dr Slavkin) and Gene Therapy and Therapeutics Branch (Dr Baum), National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Md.

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