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To the Editor: The development of diabetic retinopathy has been related to hyperglycemia-induced oxidative stress.¹ Haptoglobin (HP) is 1 of many known antioxidant proteins and is encoded by 2 different alleles, whose products differ markedly in their antioxidant ability.² Patients who are homozygous for the 1 allele (HP 1-1) form dimeric HP molecules, whereas patients who are heterozygous (HP 1-2) or homozygous (HP 2-2) for the 2 allele form multimers of 2 or more HP molecules. These multimeric HP complexes are sterically hindered from binding to hemoglobin and also have less access to the extravascular space. Thus, we hypothesized that HP genotype may predict susceptibility to diabetic retinopathy.

Methods

We determined the HP genotype and assessed for the presence of diabetic retinopathy in 52 consecutive patients with type 1 diabetes mellitus of at least 10 years' duration who presented to an outpatient clinic at the . . . [Full Text of this Article]

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