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To the Editor: 3,4-Methylenedioxymethamphetamine (MDMA) has achieved notoriety as the drug "ecstasy" and has been associated with dance events called "raves." Few reports of the content of ecstasy pills from the United States are available,¹ but European reports suggest that ecstasy commonly contains substances other than MDMA.² We sought to describe the range of drugs found in ecstasy pills in the United States.

Methods

Samples were solicited by DanceSafe, a national organization active at dance events, using a Web site (http://www.dancesafe.org) and informational tables at dance events. Individuals were informed they could anonymously mail pills to the analyzing laboratory along with a money order for the cost of the assay ($100) for each sample.

Pills were dissolved in methanol and assayed by gas chromatography–mass spectroscopy in full-scan electron impact mode (70 eV). Compounds were identified with a computerized reference library and confirmed with analytical standards. Complete methods are available . . . [Full Text of this Article]

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