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Creutzfeldt-Jakob Disease in the United States: 1979-1998
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To the Editor: Creutzfeldt-Jakob disease (CJD) is the most common transmissible spongiform encephalopathy in humans. In response to concerns about the emergence of new variant CJD (nvCJD) in the United Kingdom, the Centers for Disease Control and Prevention (CDC) enhanced its ongoing CJD surveillance.1-2 We describe results of mortality surveillance for CJD in the United States from 1979 through 1998.
Methods
We analyzed multiple cause-of-death data3 for CJD (International Classification of Diseases, Ninth Revision, code 046.1). We excluded 8 deaths because of coding errors, clear alternative diagnoses, or pathological findings indicating the absence of CJD; we included an additional 5 deaths reported to the CDC by other surveillance methods. Age-specific and age-adjusted annual CJD death rates were calculated. Age-adjusted rates were standardized by the direct method, using the 1990 census population.
Results
From 1979 through 1998, 4751 deaths due to CJD were reported in the United States (. . . [Full Text of this Article]
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