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Sean P. Keenan, MD, FRCPC

JAMA. 2000;284:2376-2378.

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

Almost 2 decades after the introduction of noninvasive positive pressure ventilation (NPPV), researchers continue to try to catch up with the necessary evaluation to answer key clinical questions about this intervention. For instance, should NPPV be used in patients with acute respiratory failure? If so, do some patients benefit more than others? Can NPPV ever cause harm in this setting? While the puzzle is not complete, each study contributes a new piece that provides a glimpse of the big picture. Two studies, in this issue of the THE JOURNAL^1-2 provide important data on the effectiveness of NPPV in acute respiratory failure.

The effect of NPPV in acute respiratory failure on outcomes, such as the need for endotracheal intubation, length of stay in the intensive care unit (ICU), duration of ventilation, and survival, varies among patients. The initial population primarily studied in randomized controlled trials was . . . [Full Text of this Article]

Author Affiliation: Royal Columbian Hospital, New Westminster, British Columbia.

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