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To the Editor: Dr Bhasin and colleagues¹ reported that testosterone replacement therapy or resistance training resulted in gains in body weight, muscle mass, strength, and lean body mass in men infected with the human immunodeficiency virus (HIV) who have weight loss and low testosterone levels. However, the training protocol does not reflect the scientific basis for effective resistance training.

Bhasin et al described a resistance training protocol that featured whole-body training with 5 exercises 3 times per week. After testing for 1-repetition maximum (1-RM), the first 4 weeks of the protocol involved 3 sets of 12 to 15 repetitions at 60% of the 1-RM. This was followed by 6 weeks of a periodized program using 4 sets of 4 to 6 repetitions with 1 day at 90% of 1-RM, 1 day at 80%, and 1 day at 70%. A similar protocol, but with 5 sets and greater resistance, was used . . . [Full Text of this Article]

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