Progress in Soft Tissue Paleopathology
Arthur C. Aufderheide, MD
JAMA. 2000;284:2571-2573.
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INTRODUCTION
Paleopathology seeks to arrive at a broader understanding of human disease by correlating the pathological findings of mummified human tissue with known historical and cultural trends. In 1978 Cockburn1 stated that "those who confine their research entirely to diseases as they exi[s]t at the present moment are operating in a two-dimensional plane: paleopathology adds a third dimension. It is like the difference between monocular and binocular vision."
Some human diseases can be diagnosed from ancient skeletal tissue, but a much greater number can be discovered by examination of preserved ancient soft tissues. Although anatomic methods remain important, paleopathological studies of soft tissue have been greatly extended by the application of new biochemical and genetic techniques.
Methods of Mummification
Mummification can be defined as the preservation of soft tissue to resist the usual enzyme-mediated process of postmortem decay. This can be brought about by environmental effects without human intervention (spontaneous . . . [Full Text of this Article]
Anatomic Methods
Biochemical Methods
Immunological Techniques Genetic Analysis
Other Methods
Implications for Public Health
Author Affiliation: Department of Pathology and Laboratory Medicine, University of Minnesota School of Medicine, Duluth.
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