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To the Editor: Guidelines for HIV (human immunodeficiency virus) postexposure prophylaxis (PEP) recommend administration of zidovudine and lamivudine with inclusion of a protease inhibitor if there is an increased risk of HIV transmission or if resistance to zidovudine and lamivudine is suspected.¹ The guidelines do not recommend the routine use of nonnucleoside reverse transcriptase inhibitors (NNRTIs), but allow for their use with expert consultation. A severe hypersensitivity reaction is a known complication of nevirapine and can present as a fulminant hepatitis,² or as a systemic syndrome with predominant cutaneous manifestations referred to as hypersensitivity syndrome (HSS) or drug rash with eosinophilia and systemic symptoms.³ We report a case of a severe systemic reaction with rash in a health care worker shortly after administration of a nevirapine-containing PEP regimen.

Report of a Case

A 33-year-old female nurse sustained a hollow-bore needlestick injury after drawing blood from a patient with advanced HIV infection (CD4 cell count, . . . [Full Text of this Article]

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