This Article  • Full text  • PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Citing articles on ISI (28)  • Contact me when this article is cited  Related Content  • Related articles  • Similar articles in JAMA  Social Bookmarking   What's this?

Brian Vastag

JAMA. 2000;284:2983-2985.

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

Washington—A long-awaited fifth revision of the Declaration of Helsinki, widely acknowledged as the foundation of medical research ethics, is receiving mixed reactions for discouraging placebos in clinical trials and mandating researchers to provide "best proven" therapy to participants after a trial.

Patient protection advocates, who lobbied hard for the new language, hail the revision as a major step toward abolishing what they see as unethical research, especially in developing nations. Delon Human, MD, secretary general of the World Medical Association (WMA), which put forth the declaration, is equally enthusiastic. He says the revision is an ideal—not a "manual of protocols and procedures"—but that it sets an ethical standard "which I don't think can be set high enough."

Or can it be? Some researchers and bioethicists are calling the recommendations on placebo use unwarranted and unnecessary, a possible bane to future research. And the US agencies responsible for . . . [Full Text of this Article]

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati     What's this?

RELATED ARTICLES

World Medical Association Declaration of Helsinki: Ethical Principles for Medical Research Involving Human Subjects
JAMA. 2000;284(23):3043-3045.
EXTRACT | FULL TEXT  

Perspectives on the Fifth Revision of the Declaration of Helsinki
Povl Riis
JAMA. 2000;284(23):3045-3046.
EXTRACT | FULL TEXT  

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Hopes for Helsinki: reconsidering "vulnerability"
Eckenwiler et al.
J. Med. Ethics 2008;34:765-766.
FULL TEXT  

Ethical Issues in Human Genome Epidemiology: A Case Study Based on The Japanese American Family Study in Seattle, Washington
Austin
Am J Epidemiol 2002;155:585-592.
ABSTRACT | FULL TEXT  

Randomized Controlled Trial of Single-Agent Paclitaxel Versus Cyclophosphamide, Doxorubicin, and Cisplatin in Patients With Recurrent Ovarian Cancer Who Responded to First-Line Platinum-Based Regimens
Cantu et al.
JCO 2002;20:1232-1237.
ABSTRACT | FULL TEXT  

Salmeterol and Inhaled Corticosteroids in Patients With Persistent Asthma
Botkin et al.
JAMA 2001;286:3075-3078.
FULL TEXT  

The Ethics of Placebo-Controlled Trials -- A Middle Ground
Emanuel and Miller
NEJM 2001;345:915-919.
FULL TEXT  

Effectiveness of St John's Wort in Major Depression: A Randomized Controlled Trial
Shelton et al.
JAMA 2001;285:1978-1986.
ABSTRACT | FULL TEXT