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Acute Myocardial Infarction and Prior Antibiotic Use
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To the Editor: Chronic infections, particularly with Chlamydia pneumoniae, may contribute to the development of atherosclerosis. Use of fluoroquinolones and tetracyclines has been associated with protection against myocardial infarction (MI).1 We performed a case-control study to determine whether patients receiving antibiotics effective against C pneumoniae were less likely to have been admitted for a first acute MI.
Methods
Data were obtained from the PHARMO system, which includes information on hospital admissions and drug-dispensing records for all 450 000 residents of 8 Dutch cities. The drug-dispensing records were obtained from pharmacy files and are linked to a nationwide database of hospital discharge records.2
We identified all persons aged 35 to 75 years with a first hospitalization (1985-1995) for MI (International Classification of Diseases, 9th Revision, Clinical Modification [ICD-9-CM] code 410) and a PHARMO registration period of at least 3 years. For each patient, we identified as many as 4 . . . [Full Text of this Article]
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