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	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

To the Editor: Ms Hu and colleagues¹ sought to identify the genetic map for pediatric gastroesophageal reflux (GER). However, the authors do not report diagnostic criteria for GER, and therefore we are concerned about the uniformity of their sample.

Children with chronic vomiting, spitting up, dysphagia, and food refusal are commonly diagnosed with GER and are treated with acid suppression. Alternatively, these symptoms may have other causes such as anatomical malformations, food allergies, functional bowel diseases, or metabolic disorders. Clinical criteria used to make an initial diagnosis of GER can be subjective, but when symptoms are refractory to medical management, patients will often undergo evaluation including esophagogastroduodenoscopy with biopsy. One emerging cause of such refractory symptoms is eosinophilic esophagitis (EE), which has been reported in at least 81 children in 4 different academic institutions.^2-5 The affected squamous epithelium contains a large number of intraepithelial eosinophils, despite at least 2 months . . . [Full Text of this Article]

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Mapping of a Gene for Severe Pediatric Gastroesophageal Reflux to Chromosome 13q14
Fen Ze Hu, Robert A. Preston, J. Christopher Post, Gregory J. White, Lee W. Kikuchi, Xue Wang, Suzanne M. Leal, Mark A. Levenstien, Jurg Ott, Thomas W. Self, Gregory Allen, Richelle S. Stiffler, Caroline McGraw, Elizabeth A. Pulsifer-Anderson, and Garth D. Ehrlich
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